TABLE 7.
ODDS RATIO ESTIMATES BY BERYLLIUM EXPOSURE AND HLA-DPB1 E69 GENOTYPE FOR ODDS OF CHRONIC BERYLLIUM DISEASE
| Lifetime Weighted Average Beryllium Exposure (μg/m3) | HLA-DPB1 E69− Genotype | Single *02 (with E69− Allele) | Single E69+ non-*02 (with E69− Allele) | E69 Homozygote (*02 plus non-*02 E69+) |
|---|---|---|---|---|
| 0.02 | 1.02 (1.00–1.03) | 3.52 (1.45–8.57) | 12.16 (5.20–28.45) | 22.90 (7.11–73.83) |
| 0.05 | 1.04 (1.01–1.07) | 3.61 (1.48–8.77) | 12.45 (5.32–29.14) | 23.46 (7.27–75.69) |
| 0.10 | 1.08 (1.02–1.15) | 3.75 (1.54 −9.14) | 12.96 (5.53–30.37) | 24.41 (7.55–78.96) |
| 0.20 | 1.18 (1.04–1.32) | 4.06 (1.66–9.95) | 14.03 (5.95–33.07) | 26.43 (8.11–86.11) |
| 0.50 | 1.49 (1.10–2.02) | 5.16 (2.02–13.16) | 17.82 (7.25–43.81) | 33.56 (9.90–113.76) |
| 1.0 | 2.22 (1.21–4.07) | 7.68 (2.63–22.43) | 26.52 (9.38–75.02) | 49.95 (13.07–190.88) |
| 2.0 | 4.91 (1.46–16.56) | 17.01 (3.80–76.17) | 58.77 (13.43–257.2) | 110.7 (19.78–619.3) |
Definition of abbreviation: E69 = glutamic acid at position 69.