Table 1.

Sixty-One Common Gene Variants at 58 Loci are Associated with Obesity Phenotypes at a Genome-Wide Level of Significance (P < 5 x 10⁸)

Nearest Gene	Polymorphism	Phenotype	Reference
FTO	rs1421085 / rs9939609	body mass index, extreme obesity	[99, 100]
MC4R	rs17782313	body mass index, extreme and childhood obesity	[107, 109, 130]
PCSK1	rs6232	extreme obesity	[74]
PCSK1	rs6234 / rs6235	extreme obesity	[74]
CTNNBL1	rs6013029	body mass index	[139]
TMEM18	rs6548238	body mass index, childhood obesity	[64, 109]
GNPDA2	rs10938397	body mass index	[64]
SH2B1	rs7498665	body mass index	[64]
KCTD15	rs11084753	body mass index	[64]
MTCH2	rs10838738	body mass index	[64]
NEGR1	rs2815752	body mass index	[64]
NPC1	rs1805081	extreme obesity	[107]
MAF	rs1424233	extreme obesity	[107]
PTER	rs10598503	extreme obesity	[107]
PRL	rs4712652	extreme obesity	[107]
SEC16B	rs10913469	body mass index	[63]
ETV5	rs7647305	body mass index	[63]
AIF1	rs2844479	body mass index	[63]
BDNF	rs6265	body mass index	[63]
BDNF	rs925946	body mass index	[63]
FAIM2	rs7138803	body mass index	[63]
FTO	rs6499640	body mass index	[63]
SDCCAG8	rs12145833	childhood obesity	[109]
TNKS	rs17150703	childhood obesity	[109]
TFAP2B	rs987237	waist circumference, body mass index	[104, 110]
MSRA	rs7826222	waist circumference	[110]
LYPLAL1	rs4846567	waist to hip ratio	[110, 113]
NRXN3	rs10146997	waist circumference, body mass index	[104, 112]
C12orf51	rs2074356	waist to hip ratio	[103]
GPRC5BB	rs12444979	body mass index	[104]
POMC	rs713586	body mass index	[104]
MAP2K5	rs2241423	body mass index	[104]
GIPR	rs2287019	body mass index	[104]
FANCL	rs887912	body mass index	[104]
TNNI3K	rs1514175	body mass index	[104]
LRRN6C	rs10968576	body mass index	[104]
FLJ35779	rs2112347	body mass index	[104]
SLC39A8	rs13107325	body mass index	[104]
TMEM160	rs3810291	body mass index	[104]
CADM2	rs13078807	body mass index	[104]
LRP1B	rs2890652	body mass index	[104]
PRKD1	rs11847697	body mass index	[104]
MTIF3	rs4771122	body mass index	[104]
ZNF608	rs48361333	body mass index	[104]
PTBP2	rs1555543	body mass index	[104]
TUB	rs4929949	body mass index	[104]
HMGA1	rs206936	body mass index	[104]
MC4R	rs7227255	body mass index	[104]
RSPO3	rs9491696	waist to hip ratio	[113]
VEGFA	rs6905288	waist to hip ratio	[113]
TBX15/WARS2	rs984222	waist to hip ratio	[113]
NFE2L3	rs1055144	waist to hip ratio	[113]
GRB14	rs10195252	waist to hip ratio	[113]
DNM3/PIGC	rs1011731	waist to hip ratio	[113]
ITPR2/SSPN	rs718314	waist to hip ratio	[113]
LY86	rs1294421	waist to hip ratio	[113]
HOXC13	rs1443512	waist to hip ratio	[113]
ADAMTS9	rs6795735	waist to hip ratio	[113]
ZNRF3/KREMEN1	rs4823006	waist to hip ratio	[113]
NISCH/STAB1	rs6784615	waist to hip ratio	[113]
CPEB4	rs6861681	waist to hip ratio	[113]