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. 2011 May;12(3):204–215. doi: 10.2174/138920211795677877

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©2011 Bentham Science Publishers Ltd

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. (3) — Scatterplot of mean normalized values with standard deviations for probes evaluated by multiplex ligation-dependent probe amplification (MLPA) with methylation-specific analysis. (A) Gene copy number of a control individual without any deletion or duplication of probes in the 15q11-q13 region or elsewhere deleted (average copy number of 2.0 for each probe). (B) Gene copy number of an individual with Prader-Willi syndrome and the typical Type I deletion of the 15q11-q13 region extending from GCP5 to OCA2 with other genes on chromosome 15 (e.g., APBA2) or other chromosomes not deleted (copy number of 1.0 = deletion; copy number of 2.0 = non-deletion). (C) Gene copy number of an individual with Prader-Willi syndrome and the typical Type II deletion of the 15q11-q13 region extending from MKRN3 to OCA2 with other genes on chromosome 15 (e.g., APBA2) or other chromosomes not deleted (copy number of 1.0 = deletion; copy number of 2.0 = non-deletion).