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Under normal conditions, free pools of Hsp70 and Hsp90 are high and pools of misfolded protein are low. Hsp90 is bound to Hsf1 to prevent transcription of heat shock genes. Hsp70 activates Mkp1 which leads to dephosphorylation of JNK and p38, so that apoptotic pathways are not activated. Thickness of lines indicates most likely reactions and states.
