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. 2011 Jul 14;6(7):e22038. doi: 10.1371/journal.pone.0022038

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Proctor, Lorimer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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ROS levels were increased by a factor of 4 at time t = 4 hours for a period of 2 hours. One typical simulation result is shown. A Native protein, total misfolded protein (includes misfolded bound by Hsps), and reactive oxygen species (ROS). ROS are scaled x100 to allow easier visualisation. B Total Hsp90 (free pools plus all complexes), Free Hsp90 (unbound Hsp90) and Hsp90_MisP (Hsp90 bound to misfolded protein). C Total Hsp70 (free pools plus all complexes), Free Hsp70 (unbound Hsp70) and Hsp70_MisP (Hsp70 bound to misfolded protein).