Table 3. Results of parameter scan for deterministic model under normal conditions.

Parameter	NatP	Total MisP	Free pool of Hsp70	Free pool of Hsp90
ksynNatP	↑ 0.079	↑ 0.075	↓ 0.018	↓ 0.018
kmisfold	↓ 0.110	↑ 0.798	↓ 0.172	↓0.173
kbinMisPProt	↓ 0.058	↓0.146	↑ 0.037	↑ 0.036
krefold	↑ 0.060	↓ 0.432	↑ 0.096	↑ 0.096
kbasalsynHsp70	↔ 0.000	↓ 0.002	↑ 0.160	↑ 0.014
kbasalsynHsp90	↔ 0.000	↓ 0.002	↑ 0.014	↑ 0.131
kbinHsp70Prot	↔ 0.000	↑ 0.002	↓ 0.152	↓ 0.015
kbinHsp90Prot	↔ 0.000	↑ 0.002	↓ 0.016	↓ 0.131
kgenROS	↓ 0.108	↑ 0.799	↓ 0.176	↓ 0.177
kremROS	↑ 0.064	↓ 0.481	↑ 0.108	↑ 0.109
kphosp38	↓ 0.005	↑ 0.033	↓ 0.007	↓ 0.007
kdephosp38Mkp1	↑ 0.002	↓ 0.017	↑ 0.004	↑ 0.004

Each parameter was scanned over 10 values ranging from half to double its initial value over a period of 10 hours. The results show the effect of increasing the parameter from its initial value on the pools of NatP, MisP (including MisP bound to Hsps and the proteasome), free pools of Hsp70 and free pools of Hsp90. The arrows show the direction of change, the numbers indicate the proportional change in the species value when the parameter value is doubled (), where the denominator is equal to one, if the parameter value k is double). Effects which are greater than 10% are indicated in boldface.