TABLE 1.
Mutation cluster patterns in clones with 2–10 mutations in the combined (AAC AGC)15 cassettes
| Mutations/clone | Cluster | Mutation clusters (%) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | ||
| 2 | Data (209)a | 92.8 | 7.2 | ||||||||
| 2 | Simulatedb | 90.4 | 9.6 | ||||||||
| 3 | Data (113) | 87.6 | 11.4 | 1.0 | |||||||
| 3 | Simulated | 83.7 | 14.6 | 1.7 | |||||||
| 4 | Data (64) | 77.0 | 19.0 | 3.0 | 1.0 | ||||||
| 4 | Simulated | 77.5 | 18.5 | 3.5 | 0.5 | ||||||
| 5 | Data (55) | 71.1 | 23.9 | 2.5 | 2.0 | 0.5 | |||||
| 5 | Simulated | 71.0 | 21.9 | 5.6 | 1.3 | 0.1 | |||||
| 6 | Data (37) | 67.3 | 24.4 | 7.1 | 1.3 | 0.0 | 0.0 | ||||
| 6 | Simulated | 65.8 | 23.4 | 7.9 | 2.2 | 0.5 | 0.1 | ||||
| 7 | Data (27) | 62.1 | 25.0 | 11.3 | 1.6 | 0.0 | 0.0 | 0.0 | |||
| 7 | Simulated | 60.4 | 25.1 | 9.7 | 3.4 | 1.1 | 0.3 | 0.0 | |||
| 8 | Data (19) | 57.4 | 29.8 | 7.4 | 4.3 | 1.1 | 0.0 | 0.0 | 0.0 | ||
| 8 | Simulated | 55.3 | 25.5 | 11.4 | 4.8 | 2.0 | 0.7 | 0.2 | 0.0 | ||
| 9 | Data (16) | 48.7 | 28.9 | 11.8 | 6.6 | 2.6 | 1.3 | 0.0 | 0.0 | 0.0 | |
| 9 | Simulated | 50.6 | 25.6 | 13.0 | 6.2 | 2.9 | 1.1 | 0.4 | 0.1 | 0.0 | |
| 10 | Data (12) | 49.2 | 25.4 | 11.9 | 3.4 | 6.8 | 3.4 | 0.0 | 0.0 | 0.0 | 0.0 |
| 10 | Simulated | 45.5 | 25.7 | 14.4 | 7.3 | 4.0 | 1.8 | 0.8 | 0.4 | 0.1 | 0.0 |
a Numbers in parentheses are the number of sequenced clones.
b Simulated refers to the modified random walk model (see text) with the following parameters: AID-catalyzed deamination efficiency in AAC motif = 3%; average slide distance obtained from geometric distribution = 30 nt (10 motifs).