TABLE 1.

Summary of SEC-MALS data

Figure panel	Proteins injected	Expected monomeric molecular mass	Expected dimeric molecular mass	MALS averaged molecular mass	Molecular state
		kDa	kDa	kDa
3A	CCM3	24.7	49.4	45.8 ± 4.4	CCM3 dimer
3B	MST4	46.7	93.4	94.0 ± 8.2	MST4 dimer
3C	MST4 kinase domain	34.0	68.0	37.9 ± 1.6	MST4 monomer
3D	CCM3+MST4 (co-purified)	24.7, 46.7	49.4, 93.4 (heterodimer, 71.4)	61.7 ± 2.0	CCM3-MST4 heterodimer
4A	CCM3 LAIL-4D	24.7	49.4	25.2 ± 2.9	CCM3 monomer
4B	CCM3 LAIL-4D+MST4	24.7, 46.7	49.4, 93.4	20.4 ± 1.0, 104.6 ± 4.9	CCM3 monomer, MST4 dimer