TABLE 3.
Transcription factor binding sites enriched in hypermethylated genes in MDS
| Transcription factors | No. of genes | p value | Genes | Motif |
|---|---|---|---|---|
| SP1 | 12 | 3.10E-05 | DOCK4, PLAGL2, ZFX, C11ORF30, DDAH2, SYNE1, SV2A, ARRDC4, SEZ6, STRN, NXT2, SLC35D1 | GGGCGGR |
| AHR | 5 | 4.19E-04 | PLAGL2, ZFX, RUNX3, ANGPTL2, VAMP3 | CCYCNRRSTNGCGTGASA |
| E12 | 14 | 3.78E-03 | PLAGL2, C11ORF30, DDAH2, SYNE1, SV2A, DUSP4, PPARGC1A, HOXB3, ADAMTS15, GIT2, ODC1, ITPK1, IQGAP2, LEPREL1 | CAGGTG |
| FOXO4 | 11 | 4.93E-03 | MDS1, HSPG2, KLF3, C11ORF30, DOCK4, DUSP4, PPARGC1A, HOXB3, HMGN3, ABCC1, DNAH11 | TTGTTT |
| NFY | 4 | 5.80E-03 | ARRDC4, ADAMTS15, JMJD2A, IMP4 | GATTGGY |
| CHX10 | 2 | 8.60E-03 | SEZ6, MDS1 | TAATTA |
| AREB6 | 2 | 9.96E-03 | ADAMTS15, SEZ6 | CAGGTA |
| MAZ | 14 | 1.22E-02 | ZFX, DDAH2, SYNE1, DOCK4, ARRDC4, RUNX3, DUSP4, ADAMTS15, MDS1, HSPG2, JMJD2A, JPH4, DAB2IP, GSPT1 | GGGAGGRR |
| GABP | 2 | 1.32E-02 | GIT2, JPH4 | MGGAAGTG |
| LEF1 | 12 | 1.60E-02 | DOCK4, SEZ6, ANGPTL2, DUSP4, PPARGC1A, HOXB3, ODC1, KLF3, DAB2IP, NUP107, FARP1, ARHGEF4 | CTTTGT |
| NF1 | 2 | 1.81E-02 | DUSP4, HCN1 | TGCCAAR |
| SOX9 | 6 | 2.05E-02 | DOCK4, HSPG2, KLF3, MBP, PCDH12, ZNF502 | NNNNAACAATRGNN |