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Binding affinities (KD) of the WW domains with various Htt-PRR peptides as determined by NMR titration
| KD (μm) | PP1 | PP3 | PP12 | PP23 | PP35 |
|---|---|---|---|---|---|
| WW1 | 683 ± 110 | 282 ± 77 | |||
| WW2 (P67T) | 1661 ± 319 | 1435 ± 216 | |||
| 2WW (P67T) | 772 ± 219 | 236 ± 131 | 308 ± 167 | 185 ± 45 | ∼10 |
