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The positions of mutations modifying PFA sensitivity in UL54 (black font) are mapped onto the chimeric DNA polymerase (cyan font) in complex with PFA. A, mutations altering PFA-binding span motif A (DXXSLYPS). B, clinically relevant mutations of the fingers domain from HCMV UL54 present side chains on the N-terminal side of helix P, close to secondary structure elements of the N-terminal domain.
