TABLE 2.
FUNCTIONAL SINGLE NUCLEOTIDE POLYMORPHISM ASSOCIATIONS WITHIN CANDIDATE GENES
| dbSNP | SNP Type | Phenotype (%) | Symbol | Description | Chr | Start Position |
|---|---|---|---|---|---|---|
| rs32922832 | exon15, 3′UTR | 24.8 | Mgat4a | Mannoside acetylglucosaminyltransferase 4, isoenzyme A | 1 | 37501401 |
| rs31320021 | intron 1 (YY1) | 30.1 | Rfwd2 | Ring finger and WD repeat domain 2 | 1 | 161162457 |
| rs32034023 | Thr1123Met | 25.9 | Tnn | Tenascin N | 1 | 162015167 |
| rs31343079 | 5′UTR (HES-1) | 22.9 | Cacybp | Calcyclin binding protein | 1 | 162133052 |
| rs27124906 | 5′UTR (GAL4) | 26.6 | Arhgap15 | Rho GTPase activating protein 15 | 2 | 43604344 |
| rs27914711 | variant 2 | 18.8 | Cacnb4 | Calcium channel, voltage-dependent, beta 4 subunit | 2 | 52532101 |
| rs6406107 | 5′UTR (ELK1) | 18.9 | Acvr1 | Activin A receptor, type 1 | 2 | 58419239 |
| rs27956803 | Gln81Arg | 25.1 | Ccdc148 | Coiled-coil domain containing 148 (BC062650) | 2 | 58674108 |
| rs51612205 | 5′UTR (NF-1) | 17.4 | Tgfbr3 | Transforming growth factor, beta receptor III | 5 | 107535589 |
| rs4228631 | Asp1Ala | 11.1 | Fancl | Fanconi anemia, complementation group L | 11 | 26287084 |
| rs48672482 | intron 1 (MTF-1) | 28.3 | Mycn | V-myc myelocytomatosis viral related oncogene, neuroblastoma derived | 12 | 12942899 |
dbSNP: single nucleotide polymorphism database identification number. SNP Type: expression SNP (eSNP) includes predicted transcription factor binding site that is lost by polymorphism in parenthesis, and nonsynonymous (cnSNP) includes amino acid substitution with location in gene between amino acid. Phenotype (%): percentage phenotype (mean survival time) difference explained by mice with either allele as a percentage of the difference of two most polar strains. Chr: chromosome location of gene. Start Position: first basepair location of gene.