Figure 7.

Proinflammatory cytokine production after ischemia–reperfusion (IR) is mediated by invariant natural killer T cells. Cytokine levels (IL-17A, MCP-1, tumor necrosis factor [TNF]-α, KC, regulated upon activation, normal T-cell expressed and secreted [RANTES], and IL-6) were measured in bronchoalveolar lavage fluid of wild-type (WT) and Jα18^−/− mice (n = 5/group). A multifold increase of each cytokine occurred after IR in WT mice compared with sham, which was significantly attenuated in Jα18^−/− mice. *P < 0.001 versus WT sham, ^#P < 0.05 versus WT IR.