Table 3.
Effects of 3-NPA with and without Acetyl-L-Carnitine Pretreatment on Gene Expression in PC12 Cells
| GENES | 3-NPA | Acetylcarnitine/3-NPA | ||
|---|---|---|---|---|
| Change | P values | Change | P values | |
| Apoptosis | ||||
| Parp-1 | ||||
| Tp53 | down | p = 0.009 | ||
| Pdcd8 (AIF) | up | p = 0.05 | ||
| Bcl2 | ||||
| Bax | ||||
| Inflammation | ||||
| Il10 | down | p = 0.024 | down | p = 0.007 |
| Il1rn | ||||
| Nr3c1 | ||||
| Cxcr4 | ||||
| Ptgs1 (Cox1) | up | p ≤ 0.001 | up | p ≤ 0.001 |
| Transporters | ||||
| Slc17a7 | up | p ≤ 0.001 | ||
| Slc25a20 | up | p = 0.018 | ||
| Slc25a14 (ucp5) | ||||
| Heat Shock Proteins | ||||
| Hsp27 | up | p ≤ 0.001 | ||
| Hmox1 ( Hsp32, HO1) | up | p = 0.024 | ||
| Hspa 1a (Hsp70) | up | p = 0.009 | ||