Fig. (2). Effect of TsA and PhB on the combination of cocaine- and cue-induced reinstatement of cocaine-seeking behavior.

Rats were i.v. injected daily with vehicle or with the indicated HDAC inhibitor, beginning 4 days before the reinstatement session. They were treated again 30 min before being injected i.p. with 15 mg/kg cocaine and placed immediately in the self-administration chamber. Numbers of NPs, expressed as means ± sem, realized in the active and inactive holes during the 1-h test session are shown. *p < 0.05, comparison between pharmacological and vehicle treatment (One-way Kruskal-Wallis ANOVA followed by Dunn’s post hoc test).