Fig. (5).

Effects of chronic administration of ketamine on total activity and habituation into the open-field arena. Male Wistar rats were treated with 5 mg/kg of ketamine and 10mg/kg of ketamine (K 10mg, n=9), in 12 h intervals. The control group received an isovolumetric dose of saline solution following the same protocol (Saline, n=10). The results were represented as the mean ± standard error (expressed as counts in 10 min sessions). Significant differences were signed as ♦p<0.05 or ♦♦♦p<0.001.