Table 2.

Changes in the Transport Kinetics Induced by Methylone and Methamphetamine in CHO Cells Stably Expressing the Monoamine Transporters

	Km (µM)	Vmax (fmol/µg protein/min)
DAT
Control	1.73 ± 0.55	34.12 ± 7.64
Methylone 5µM	2.33 ± 0.67	26.68 ± 8.70
Methamphetamine 1µM	2.06 ± 0.83	24.18 ± 9.89
NET
Control	0.25 ± 0.03	3.63 ± 0.31
Methylone 0.5µM	0.58 ± 0.10*	4.54 ± 1.01
Methamphetamine 0.2µM	0.71 ± 0.20	4.69 ± 0.49
SERT
Control	0.27 ± 0.04	40.68 ± 7.23
Methylone 10µM	1.12 ± 0.25*	36.95 ± 5.68
Methamphetamine 30µM	0.86 ± 0.21*	31.41 ± 4.63

Values represent the mean ± SEM for three experiments each performed in triplicate.

^*P<0.05 vs control.