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. 2011 Mar;9(1):96–99. doi: 10.2174/157015911795016985

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©2011 Bentham Science Publishers Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. (3) — Enhanced MDMA-induced hyperthermia in heterozygous and homozygous parkin knockout mice compared with wildtype mice. (A) Change in body temperature in mice injected with MDMA (30 mg/kg, i.p.). Body temperature areas-under-the-curve were analyzed by repeated-measures ANOVA (Genotype, F_2,55 = 6.746, p = 0.0024; Time, F_4,220 = 61.267, p < 0.0001; Genotype × Time interaction, F_8,220 = 3.664, p = 0.0005) followed by Scheffe’s post hoc test (*p < 0.05, **p < 0.01). (B) Change in body temperature areas-under-the-curve (TAUC) shown as an integration of the temperature vs. time curve shown in panel A. TAUC values were analyzed by one-way ANOVA (F_2,55 = 6.746, p = 0.0024) followed by Scheffe’s post hoc test (*p < 0.05, **p < 0.01).