Table 4.

Effect of Time Horizon and Age on the Cost-effectiveness of Aspirin and Aspirin+PPI in Men With 10-Year, 10%, CHD

	Time Horizon
Age (Years)	5 Years	10 Years	25 Years	Lifetime
Aspirin vs. No Treatment
45	More effective, less costly	More effective, less costly	More effective, less costly	More effective, less costly
55	More effective, less costly	More effective, less costly	More effective, less costly	More effective, less costly
65	$1,120	More effective, less costly	More effective, less costly	$50
Aspirin+PPI vs. Aspirin Alone
45	$2,513,270	$1,974,339	$1,010,770	$447,077
55a	$702,561	$531,451	$250,420	$175,641
65	$712,499	$537,048	$290,968	$276,984

CHD = coronary heart disease; PPI = proton pump inhibitor; QALY = quality-adjusted life year.

^aIncremental cost per QALY from 55 to 65 years of age reduces, although the risks of myocardial infarction and CHD deaths increase, because the cost of the PPI outweighs the benefit of including the PPI.