. Author manuscript; available in PMC: 2011 Aug 14.

Published in final edited form as: Arch Intern Med. 2011 Feb 14;171(3):218–225. doi: 10.1001/archinternmed.2010.525

Table 5.

Estimated Baseline Risk per 1,000 Patient-Years of Gastrointestinal Bleeding in Men With No History of Ulcer

Age (Years)	No NSAID or SSRI^a	SSRI Use, No NSAID^b	NSAID Use, No SSRI^a	NSAID and SSRI Use^c

Less than 60	0.8	1.9	3.2	4.8
60–69	2.4	5.8	9.6	14.4
70–79	3.6	8.6	14.4	21.6

80–89	6.0	14.4	24.0	36.0

NSAID = nonsteroidal anti-inflammatory drug; SSRI= selective serotonin reuptake inhibitor.

From Hernandez-Diaz et al.⁶

Odds ratio = 2.4.²⁰

Odds ratio = 6.0.²⁰

The risk in this table is for men with no ulcer-related bleeding and assumes that the relative risks approximate the odds ratios and that the relative risks are independent. For estimating gastrointestinal bleeding risk for patient with previous history of uncomplicated ulcer, multiply by 6; multiply by 10 for history of complicated ulcer.