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. Author manuscript; available in PMC: 2011 Jul 15.
Published in final edited form as: Nature. 2010 Oct 28;467(7319):1109–1113. doi: 10.1038/nature09460

Figure 3.

Figure 3

Phylogenetic relationships among different metastases and the primary tumour. (A) Results of PCR genotyping for 23 rearrangements across 19 metastases and the primary tumour from patient PD3637. (B) Phylogenetic tree showing the relatedness of different metastases and the primary tumour. Note the early divergence of the primary tumour from all metastases. (C) Genotyping results for PD3638, as well as (D) PD3639, (E) PD3641, (F) PD3643 and (G) PD3642. (H) Circle plot showing that the rearrangements generating the amplicon of KRAS on chromosome 12 in PD3642 were only found in the index metastasis sequenced, and none of the other metastases or the primary tumour.