Table II.
Outcome of thawing frozen embryos for couples wishing an autologous transfer and for those couples consenting to the embryos being observed and then discarded.
| Embryos frozen in a medium containing |
P-value | ||
|---|---|---|---|
| 0.1 M sucrose (control) | 0.3 M sucrose (intervention) | ||
| Number of couples randomized | n = 99 | n = 102 | |
| Number (%) of couples with ≥1 embryo thawed | 74 (75%) | 63 (62%) | 0.07 |
| Median (IQR) number of embryos thawed | 3 (0, 4) | 2 (0, 4) | 0.06 |
| Median (IQR) number of thawing cycles | 1.(0, 1) | 1 (0, 1) | 0.23 |
| Number of thawing cycles | |||
| 0 | 25 (25%) | 39 (38%) | |
| 1 | 51 (52%) | 39 (38%) | |
| 2 | 15 (15%) | 13 (13%) | |
| 3 | 5 (5%) | 8 (8%) | |
| 4–6 | 3 (3%) | 3 (3%) | |
| Total number of couples with embryo(s) thawed and morphology recordeda | n = 74 | n = 63 | |
| Number (%) of couples with ≥50% embryos fully intact over all thawing cycles | 45/74 (61%) | 53/63 (84%) | 0.005b |
| Number of couples having embryos thawed with intention of autologous transferc | n = 67 | n = 59 | |
| Median (IQR) number of frozen embryos transferredd | 2 (2, 3) | 2 (2, 4) | 0.18 |
| Median (IQR) proportion of embryos thawed that were transferred | 0.67 (0.5, 0.8) | 0.71 (0.5, 1.0) | 0.02 |
aIncludes couples intending embryo transfer and those who allowed the embryos to be thawed and scored before being discarded.
bLogistic regression with adjustment for number of embryos thawed, female age, parity (yes/no), couple diagnosis (male only, female only, male and female).
cOne couple had embryos thawed for autologous transfer and also two embryos thawed for donation, these two embryos have not been included in further analysis.
dFresh embryos transferred in mixed transfers are not included.