Table 3. Hazard ratios for association between BMI at age 20 years and CRC risk for MMR gene mutation carriers and non-carriers.
| Total number | Total person-years | CRC number (%) |
Univariable analysis
|
Multivariable analysis
|
|||
|---|---|---|---|---|---|---|---|
| HR (95% CI)a | P | HR (95% CI)a,b | P | ||||
| Carriers | |||||||
| BMI (per 5 kg m–2) | 1324 | 58 868 | 659 (50) | 1.33 (1.11–1.58) | 0.002 | 1.30 (1.08–1.58) | 0.007 |
| WHO classification | |||||||
| Underweight | 121 | 5353 | 54 (45) | 0.91 (0.60–1.38) | 1.04 (0.66–1.64) | ||
| Normal | 909 | 41 014 | 450 (50) | 1.00 (referent) | 1.00 (referent) | ||
| Overweight | 233 | 9971 | 118 (51) | 1.17 (0.83–1.63) | 0.01 | 1.12 (0.78–1.62) | 0.06 |
| Obese | 61 | 2530 | 37 (61) | 2.40 (1.35–4.27) | 2.35 (1.30–4.23) | ||
| Non-carriers | |||||||
| BMI (per 5 kg m–2) | 1219 | 63 436 | 36 (3) | 1.86 (1.24–2.77) | 0.002 | 1.64 (1.02–2.64) | 0.04 |
| WHO classification | |||||||
| Underweight | 113 | 6157 | 3 (3) | 0.81 (0.23–2.88) | 1.01 (0.28–3.73) | ||
| Normal | 904 | 47 641 | 25 (3) | 1.00 (referent) | 1.00 (referent) | ||
| Overweight | 158 | 7694 | 6 (4) | 3.28 (1.09–9.84) | 0.01 | 3.62 (1.05–12.55) | 0.05 |
| Obese | 44 | 1944 | 2 (5) | 4.98 (1.17–21.23) | 3.00 (0.60–14.97) | ||
Abbreviations: BMI=body mass index; CI=confidence interval; CRC=colorectal cancer; HR=hazard ratio; MMR=mismatch repair.
a
With robust variance estimation for familial correlation in risk.
b
Adjusted for sex, country, cigarette smoking and alcohol drinking in both carriers and non-carriers; and further adjusted for specific MMR gene mutated in carriers.