Table 4. HR for association between BMI (per 5 kg m–2) at age 20 years and CRC risk separately for carriers of mutation in each MMR gene.
| MMR gene mutated | Total number | Total person-years | CRC cases number (%) | Median age of diagnosis (range) | HR (95% CI)a | P |
|---|---|---|---|---|---|---|
| MLH1 | 500 | 21 449 | 273 (55) | 41 (17–73) | 1.36 (1.04–1.77) | 0.03 |
| MSH2 | 648 | 28 560 | 308 (48) | 44 (17–91) | 1.28 (0.96–1.70) | 0.09 |
| MSH6 | 117 | 5870 | 40 (34) | 50 (22–72) | 0.84 (0.38–1.80) | 0.62 |
| PMS2 | 59 | 2989 | 38 (64) | 49 (30–74) | 1.52 (0.48–4.85) | 0.48 |
| MLH1 and PMS2 (MutLα heterodimer) | 559 | 24 438 | 311 (56) | 43 (17–74) | 1.36 (1.05–1.76) | 0.02 |
| MSH2 and MSH6 (MutSα heterodimer) | 765 | 34 430 | 348 (45) | 45 (17–91) | 1.26 (0.96–1.65) | 0.09 |
Abbreviations: BMI=body mass index; CI=confidence interval; CRC=colorectal cancer; HR=hazard ratio; MMR=mismatch repair.
a
adjusted for sex, country, cigarette smoking and alcohol drinking with robust variance estimation for familial correlation in risk.