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. 2011 Jun 14;105(1):139–145. doi: 10.1038/bjc.2011.191

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Copyright © 2011 Cancer Research UK

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Derivation of a thresholded parameter map to enable calculation of enhancing fraction (E_F) and box dimension (d₀). (A) K^trans map across a single slice within a CRC liver metastasis shows marked spatial heterogeneity. (B) A criterion is applied to the contrast agent concentration time series to identify enhancing voxels (N_E) and the resultant map is shown. E_F is calculated as the ratio of N_E to the number of tumour voxels (N_T). (C) A box surrounding the object defined by the enhancing voxels is successively divided, defining a range of scales (s) at which the number of boxes containing a part of the object is counted (n). (D) d₀ is the slope of the line of best fit through the points (log n, log 1/s) and quantifies the space filling properties of the parameter map.