Table 3. Adverse events of special interest to chemotherapy and key events pooled by body system (treatment-related and unrelated).

	FOLFOX4/FOLFOX4-placebo (n=648)				XELOX/ XELOX-placebo (n=655)
	All-grade		Grade 3/4		All-grade		Grade 3/4
	No.	%	No.	%	No.	%	No.	%
All events	644	99	506	78	649	99	468	72
Body system
Gastrointestinal disorders	603	93	167	26	606	93	216	33
Blood/lymphatic disorders	448	69	318	49	312	48	104	16
Infections/infestations	292	45	66	10	210	32	45	7
Events of special interest
Neurosensory toxicitya	515	80	107	17	534	82	114	17
Diarrhoea	394	61	74	11	429	66	133	20
Nausea/vomiting	452	70	47	7	464	71	52	8
Stomatitis	242	37	13	2	140	21	8	1
Neutropenia/granulocytopenia	379	59	282	44	180	28	46	7
Febrile neutropenia	—	—	31	5	—	—	6	<1
Hand-foot syndrome	70	11	8b	1b	201	31	40b	6b

Abbreviations: FOLFOX4=infused 5-fluorouracil, folinic acid and oxaliplatin; XELOX=capecitabine and oxaliplatin.

^aPooled term that includes burning sensation, dysaesthesia, hyper or hypoaesthesia, neuropathic pain, neuropathy, peripheral neuropathy, neurotoxicity, paraesthesia, peripheral (sensi)motor neuropathy, (chronic) polyneuropathy, sensory disturbance or loss, skin burning sensation, temperature intolerance, neuralgia, peroneal nerve palsy, autonomic neuropathy.

^bGrade 3 events only.