Figure 1.
Wild-type (WT) and LXR DKO(KO) mice were treated with GW3965 or vehicle for 10 days and RCT study was performed with J774 macrophages as described in Methods (n=6/each group). (A) [3H]-cholesterol in plasma after macrophages injection in wild-type mice. (B) [3H]-cholesterol in plasma after macrophages injection in LXR DKO mice. (C) [3H]-cholesterol in liver. (D) [3H]-tracer distribution in feces. *p<0.05. Data are expressed as mean ± SD.
