Table 3b.
Selenium molecular-biology biomarkers: longitudinal analysis
| Variable | Quartile* | Week 2 (n = 20) | Week 8 (n = 20) | Week 17 (n = 20) | Week 23 (n = 20) | Mean | p-value† |
|---|---|---|---|---|---|---|---|
| GPX1 mRNA (%) | 1st | 41 (18)‡ | 117 (69) | 74 (47) | 61 (15) | 73 (49) | NSI |
| 2nd | 81 (18) | 105 (44) | 83 (39) | 91 (35) | 90 (34) | NS | |
| 3rd | 153 (14) | 305 (276) | 255 (237) | 140 (41) | 213 (182) | NS | |
| 4th | 238 (68) | 299 (125)a | 155 (75)b | 126 (64)b | 204 (106) | 0.024 | |
| Mean | 128 (84) | 206 (174) | 142 (139) | 104 (50) | NS | ||
| GPX3 mRNA (%) | 1st | 46 (19) | 131 (116) | 60 (19) | 65 (23) | 75 (65) | NS |
| 2nd | 78 (10) | 143 (97) | 91 (47) | 91 (21) | 101 (57) | NS | |
| 3rd | 128 (11) | 202 (144) | 155 (98) | 104 (62) | 147 (93) | NS | |
| 4th | 237 (32) | 280 (123) | 220 (132) | 192 (145) | 232 (112) | NS | |
| Mean | 122 (77) | 189 (123) | 131 (101) | 113 (88) | NS | ||
| GPX4 mRNA (%) | 1st | 45 (15) | 88 (68) | 77 (35) | 88 (55) | 75 (47) | NS |
| 2nd | 101 (12) | 127 (62) | 98 (53) | 110 (56) | 109 (47) | NS | |
| 3rd | 135 (06) | 132 (70) | 118 (50) | 124 (56) | 127 (48) | NS | |
| 4th | 191 (57) | 296 (178) | 257 (167) | 209 (131) | 238 (136) | NS | |
| Mean | 118 (61) | 161 (127) | 137 (112) | 133 (88) | NS | ||
| Selenoprotein P mRNA (%) | 1st | .29 (20) | 52 (40) | 102 (82) | 67 (42) | 62 (54) | NS |
| 2nd | .80 (08) | 63 (16) | 126 (145) | 80 (28) | 87 (72) | NS | |
| 3rd | 130 (14) | 92 (43) | 225 (230) | 125 (38) | 143 (120) | NS | |
| 4th | 439 (178) | 297 (73) | 467 (292) | 440 (247) | 411 (208) | NS | |
| Mean | 169 (183) | 126 (111) | 230 (238) | 178 (196) | NS | ||
| Selenoprotein W mRNA (%) | 1st | 37 (20) | 183 (158) | 74 (32) | 113 (59) | 102 (97) | NS |
| 2nd | 104 (18) | 104 (71) | 129 (51) | 162 (73) | 125 (59) | NS | |
| 3rd | 155 (17) | 136 (66) | 151 (50) | 114 (64) | 139 (51) | NS | |
| 4th | 220 (61) | 242 (224) | 158 (59) | 193 (187) | 203 (143) | NS | |
| Mean | 129 (77) | 166 (144) | 128 (56) | 145 (106) | NS | ||
| Selenoprotein H mRNA (%) | 1st | 53 (26) | 121 (59) | 105 (32) | 105 (29) | 96 (44) | NS |
| 2nd | 105 (11) | 148 (47) | 106 (30) | 104 (40) | 115 (37) | NS | |
| 3rd | 128 (08) | 132 (50) | 136 (19) | 120 (10) | 129 (26) | NS | |
| 4th | 167 (23) | 183 (73) | 163 (36) | 181 (67) | 174 (50) | NS | |
| Mean | 113 (46) | 146 (59) | 127 (37) | 128 (50) | NS |
NS = Not significant
*
Quartiles sorted by week 2 values.
†
Significance level P <0.05 by 1-way ANOVA.
‡
Values are mean (SD).