Table 3. Pathway analysis.

		NCBI	Observed	Expected	Over/under	P	P*
Pathways	n.s.
Biological process
HDL-C	Lipid, fatty acid and steroid metabolism	770	5	0.42	+	4.05 × 10−5	1.26 × 10−3
	Lipid and fatty acid transport	131	3	0.07	+	4.77 × 10−5	6.91 × 10−3
LDL-C	Lipid, fatty acid and steroid metabolism	770	4	0.51	+	1.46 × 10−3	4.52 × 10−2
	Lipid and fatty acid transport	131	3	0.09	+	8.81 × 10−5	1.28 × 10−2
TG	n.s.
TC	Lipid, fatty acid and steroid metabolism	770	6	1.21	+	1.22 × 10−3	3.78 × 10−2
	Lipid and fatty acid transport	131	4	0.21	+	5.55 × 10−5	8.05 × 10−3
	Transport	1306	8	2.05	+	8.47 × 10−4	2.63 × 10−2
Molecular function
HDL-C	Lipase	75	3	0.04	+	9.11 × 10−6	1.47 × 10−3
LDL-C	Apolipoprotein	23	2	0.02	+	1.10 × 10−4	1.77 × 10−2
	Transfer/carrier protein	327	3	0.22	+	1.26 × 10−3	3.66 × 10−2
TG	n.s.
TC	n.s.

Enrichment of a particular ‘pathway', ‘biological process' or ‘molecular function' PANTHER categories were tested by pathway analysis. SNPs that are included in the pathway analysis are selected based on their P_discovery values, which were 10⁻⁶ for LDL-C, 10⁻⁵ for total cholesterol, 5 × 10⁻⁸ for HDL-C and 10⁻⁷ for triglycerides. NCBI, number of genes that belong to the particular category. Observed: number of genes that belong to the given particular category among GWAS results. Expected, expected value for number of genes that belong to the particular pathway among GWAS results. Over/under, stands for ‘over-represented/under-represented'. n.s., no significant findings. ^*P-value corrected for multiple testing.