Table 1.

Summary of NuMA interacting proteins

Stage	Interacting partner	NuMA interacting domain	Comments	Reference
Interphase	Importin	NLS in C-terminus	RanGTP/RCC1 dependent	[31]
	GAS41 (Glioma-Amplified-Sequence 41)	C-terminal coiled-coil	Ubiquitous, essential transcription factor amplified in human gliomas	[78]
	MARs (Matrix Associated Regions)	S/TPXX motifs in N- and C-termini	300–1,000bp DNA regions, 70% A+T rich; transcriptional enhancer activity	[8]
Mitosis	Dynein/dynactin		Minus end directed motor	[17]
	Microtubules	Residues 1900–1971 in C-terminus		[7]
	Rae1	Residues 325–829 in N-terminus of coiled-coil	Binds microtubules; role with NuMA in microtubule bundling	[38]
	Emi1	Binds NuMA/dynein complex	APC inhibitor, part of END (Emi1, NuMA, Dynein) complex	[28]
	LGN	Residues 1878–1910 in C-terminus	Negative regulator of NuMA function; competes with microtubules for binding to overlapping domains in NuMA C-terminus	[7, 45]
Asymmetric division	LGNa, GPR1/2b, Pinsc		LGN binds NuMA and Gα; Pins binds Mud and Gαi	[42, 52, 44]
	Dynein		Minus end directed motor	[55]

^a– human, C. elegans, Drosophila melanogaster homologs, respectively

^b– human, C. elegans, Drosophila melanogaster homologs, respectively

^c– human, C. elegans, Drosophila melanogaster homologs, respectively