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. Author manuscript; available in PMC: 2011 Jul 15.
Published in final edited form as: Annu Rev Genet. 2009;43:143–166. doi: 10.1146/annurev-genet-102108-134205

Figure 1.

Figure 1

Role of active DNA demethylation in establishing DNA methylation patterns. DNA methylation patterns are established by the combined actions of DNA methyltransferases and demethylases. Demethylases are required for pruning unwanted DNA methylation generated by promiscuous methyltransferases, and DNA methylation reprogramming/remodeling during development and in response to environmental changes.