Table 5.
Values of model parameters descriptive of NQO1-mediated DQ reduction in normoxic and hyperoxic lungs estimated from the steady-state DQH2 efflux rates during DQ infusion in the presence of antimycin A
|
Vmax1 |
|||
|---|---|---|---|
| μmol/min | μmol · min−1 · g dry wt−1 | Kma1, μM | |
| Normoxic | 1.38 ± 0.07 | 6.4 ± 0.3 | 1.0 |
| Hyper-60 | 1.84 ± 0.06 | 7.8 ± 0.5 | 1.0 |
| Hyper-85 | 4.11 ± 0.39*† | 10.8 ± 0.7*† | 1.0 |
Values are means ± SE; n = 5 for all three groups. Vmax1, maximum duroquinone (DQ) reduction rate; Kma1, apparent Michaelis-Menten constant. DQH2, durohydroquinone. Significantly different from * normoxic and † hyper-60 values, P < 0.05.