Table 2.
Effects of FME on serum alkaline phosphatase activity and urinary Ca and DPD contents in OVX rats.
| Drugs | Dose | ALP | Urinary Ca | Urinary DPD |
|---|---|---|---|---|
| (mg kg−1) | (IU l−1) | (mg mmol−1 Crea.) | (nmol mmol−1 Crea.) | |
| Sham | — | 120.6 ± 24.6** | 39.7 ± 21.0** | 292.4 ± 58.7*** |
| OVX + H2O | — | 167.1 ± 25.0 | 89.3 ± 40.3 | 520.7 ± 97.0 |
| OVX + FME | 50 | 160.9 ± 38.5 | 52.5 ± 12.4 | 444.7 ± 104.2 |
| 250 | 156.3 ± 12.5 | 39.3 ± 20.3* | 384.5 ± 106.2* | |
| 500 | 150.6 ± 20.0 | 37.3 ± 15.3** | 380.4 ± 69.5* | |
| OVX + Alen | 2.5 | 163.5 ± 24.0 | 45.2 ± 14.8** | 281.2 ± 52.3*** |
All values are mean ± SD (n = 8). Alen, alendronate; ALP, alkaline phosphatase; Crea., creatinine.
*P < .05, **P < .01, ***P < .001, versus the OVX + H2O group.