Table 3. PolyPhen2 HumVar results of familial missense variants in PRSS56.

Mutation	Result	Score	Sensitivity	Specificity
R176G	Possibly Damaging	0.522	0.82	0.81
G237R*	Probably Damaging	0.940	0.64	0.92
V302F*	Benign	0.480	0.83	0.80
W309S	Probably Damaging	0.989	0.48	0.96
G320R*	Probably Damaging	0.991	0.45	0.97
C395R*	Probably Damaging	0.923	0.66	0.91
P599A	Benign	0.001	0.99	0.08

*Denotes variants observed in the present study.