Table 2.
Antioxidation-related miRNAs differentially expressed in old kidney and their target genes
| miRNA Upregulated | Target Gene Symbol | Target Gene Name Predicted |
|---|---|---|
| rno-miR-132, 335, 351 | Gpx2 | Glutathione peroxidase 2 |
| rno-miR-184 | Gpx3 | Glutathione peroxidase 3 |
| rno-miR-223, 21 | Gpx5 | Glutathione peroxidase 5 |
| rno-miR-333 | Gpx6, Gpx7 | Glutathione peroxidase 6, 7 |
| rno-miR-340-5p | Gsta2 | Glutathione S-transferase a2 |
| rno-miR-333 | Gstt1 | Glutathione S-transferase t1 |
| rno-miR-214 | Gstz1, Gstm1 | Glutathione S-transferase z1, m1 |
| rno-miR-335 | SOD2 | Mitochondrial superoxide dismutase |
| rno-miR-184, 7a | SOD3 | Extracellular superoxide dismutase |
| rno-miR-224, 7a | CAT | Catalase |
| rno-miR-335, 708, 542–3p, 7a Txnl1 | Thioredoxin-like protein 1 | |
| rno-miR-224 | Txnl2 | Thioredoxin-like protein 2 |
| rno-miR-132, 142-5p, 708 Txnl5 | Thioredoxin-like protein 5 | |
| rno-miR-132, 212 | Txnrd1 | Thioredoxin reductase 1 |
| rno-miR-708, 34a | Txnrd2 | Mitochondrial thioredoxin reductase 2 |
| rno-miR-334 | Txndc9 | Thioredoxin domain-containing protein 9 |
| rno-miR-34c | Txndc11 | Thioredoxin domain-containing protein 11 |
| rno-miR-34c | Prdx2 | Peroxiredoxin 2 |
| rno-miR-708 | Prdx3 | Peroxiredoxin 3 |
| rno-miR-333, 351 | MT | Metallothionein |