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. 2011 Jul;22(7):1286–1296. doi: 10.1681/ASN.2010080860

Figure 4.

Figure 4.

Sulf-deficient mice develop glomerular disease. (A) Urine albumin/creatinine ratio. Each symbol represents one animal. Different symbols represent different genotypes. (B) PAS staining reveals sclerotic changes (arrow) in Sulf1−/−;Sulf2−/− mice (n = 5; GSI: 1.65, 1.84, 1.85, 1.96, 2.28) as compared with controls (n = 5; GSI: 1.15, 1.16, 1.28, 1.48, 1.55). (C) Transmission electron micrograph demonstrating partial foot process effacement (arrow), thickening of the GBM with an expansion of the subendothelial space (asterisk), and loss of endothelial cell fenestration (arrowhead) in Sulf1−/−;Sulf2−/− mice (n = 2) as compared with a control (n = 1). Right-hand panels are magnifications of the left-hand panels. Size bars = 500 nm.