Table 4.

Exploration of risk factors as intermediaries in the association of race/ethnicity and incident CKD in MESA, stratified by baseline eGFRcys

Race	N	No. Event	Rate per Year	Model 1a RR (95% CI)	P	Model 2b RR (95% CI)	P	Model 3c RR (95% CI)	P
eGFR-cysC >90 ml/min per 1.73 m2 at baseline
white	1139	5	0.09	Ref		Ref		Ref
Chinese	439	3	0.14	1.36 (0.28, 6.52)	0.70	2.23 (0.40, 12.40)	0.36	2.13 (0.36, 12.53)	0.41
black	897	14	0.34	3.40 (1.15, 10.06)	0.03	3.59 (1.20, 10.78)	0.02	2.42 (0.78, 7.48)	0.12
Hispanic	690	10	0.30	2.27 (0.62, 8.34)	0.22	2.77 (0.69, 11.18)	0.15	2.57 (0.60, 10.99)	0.20
eGFR-cysC 60 to 90 ml/min per 1.73 m2 at baseline
white	801	69	1.85	Ref		Ref		Ref
Chinese	178	9	1.09	0.59 (0.31, 1.14)	0.12	0.62 (0.32, 1.21)	0.16	0.52 (0.27, 1.00)	0.05
black	490	58	2.63	1.33 (0.96, 1.85)	0.08	1.29 (0.92, 1.82)	0.14	1.08 (0.77, 1.52)	0.64
Hispanic	456	49	2.32	1.08 (0.75, 1.55)	0.67	1.09 (0.76, 1.56)	0.64	0.91 (0.63, 1.33)	0.64

^aModel 1: adjusted for age, gender, income, education, and baseline eGFR-cysC.

^bModel 2: further adjusted for HDL, LDL, CRP, and BMI.

^cModel 3: further adjusted for DM and HTN.