Figure 2.

Decreased nephrogenic zone width, increased number of glomerular generations, and increased renal corpuscle size in kidneys from preterm neonates. (A) Nephrogenic zone width, (B) glomerular generation number, and (C) mean renal corpuscle cross-sectional area in kidneys from gestational controls (white bars; 6 neonates with completed nephrogenesis were not included in A and B) and preterm neonates (black bars; 4 neonates with completed nephrogenesis were not included in A and B), grouped by postconceptional age. The number of neonates in each group is indicated on the bars. Average nephrogenic zone width was significantly less in preterm neonates compared with gestational controls (A). The number of glomerular generations significantly increased with increasing postconceptional age, and was significantly greater in the preterm neonates compared with the gestational controls (B). Mean renal corpuscle cross-sectional area was significantly larger in the preterm neonates compared with the gestational controls (C). Bars represent mean ± SEM. PA, postconceptional age; PP, prematurity; PAxP, interaction.