Table 1. Elevated ΔNp63α levels enhance malignant conversion in v-rasHa-expressing keratinocytes.
Normal Skin | Papilloma | Carcinoma | Total | Conversion rate | |
Lenti-GFP | 10 | 0 | 0 | 10 | 0% |
Lenti-ΔNp63α | 10 | 0 | 0 | 10 | 0% |
Lenti-GFP/v-rasHa | 11 (73.3%) | 4 (26.7%) | 0 | 15 | 0% |
Lenti-ΔNp63α/v-rasHa | 0 | 0 | 20 (100%) | 20 | 100% |
Tumor incidence and conversion rate of grafted keratinocytes are presented at 5 weeks post-grafting. Tumor phenotypes were confirmed histologically.