Figure 2. Treatment with anti-IL-11 antibodies significantly attenuates the severity of TB in I/St mice.

(A) ∼3-fold decrease in lung CFU counts compared to control animals. (B and C) Lung pathology in individual animals. None of anti-IL-11-treated mice developed necrotic TB foci evident in control mice a, d and g (circled). (D) Statistical evaluation of the proportion of inflamed lung tissue. CFU counts and morphometry were performed in all mice included in 2 independent experiments (total N = 16 and 17 for experimental and control groups, respectively). Histology is displayed for individual mice analyzed in one experiment (N = 7 for each group).