Figure 5. Randomly occurring GABA_A conductance transients underlie the frequency-dependent tuning of pyramidal cell discharge fidelity.

a, Superimposed (10) Vm fluctuations of the LIF model in response to a DC step (2 s) that allows a firing rate of 5 spikes/s, in control conditions (green, 95 pA), when the LIF model received 33 randomly occurring GABA_A events/s (blue, 111 pA), an invariable pattern of 33 GABA_A events/s (red, 110 pA), or when the neuron model received a constant G_GABA-A equivalent to the average conductance for a rate of 33 events/s (orange, 110 pA). b up, Raster plot of spike times collected from 50 consecutive trials in the various conditions depicted in a; down, Spike probability over time for these 50 consecutive trials.