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. 2011 Jul 15;6(7):e22322. doi: 10.1371/journal.pone.0022322

Figure 6. Reversal potential-dependent tuning of pyramidal cell excitability and discharge fidelity.

Figure 6

a, Superimposed (5) Vm fluctuations of a whole-cell L2/3 pyramidal neurone in response to a DC step (1 s, 170 pA) in control conditions (green), when 33 randomly occurring GABAA events/s were dynamically injected at EGABA = −70 mV (blue) or −30 mV (red). Same cell and colour code for b, c and d. b, Waterfall view of Vm when the 5th spike was set as the time reference. c, Mean firing rate vs DC step. d, CVISI vs firing rate. e, Normalised changes in excitability observed when neurons received 33 randomly occurring GABAA dynamic currents/s at various differences between EGABA and the calculated threshold for AP in each individual cell (n = 9). f, Normalised changes in spike jitter observed for a firing rate of 10 spikes/s. Same conditions as in e.