Figure 7. Frequency and reversal potential-dependent tuning of pyramidal cell excitability and discharge fidelity.

a, Superimposed (5) Vm fluctuations of the LIF model in response to a DC step (1 s, 160 pA) in control conditions (green), when the LIF model received 33 randomly occurring GABA_A events/s at E_GABA = −70 mV (blue) or −35 mV (red). Same colour code for b, c and d. b, Waterfall view of Vm when the 5^th spike was set as the time reference. c, Mean firing rate vs DC step. d, CV_ISI vs firing rate. e, Normalised changes in excitability observed when LIF model received 33 randomly occurring GABA_A events/s at various E_GABA in control conditions (black), when GABA activity induced only transient changes in I_GABA-A (gray) or when GABA activity induced only transient changes in R_in (light gray). f, Normalised changes in spike jitter observed for a rate of 10 spikes/s. Same conditions as in e. g, From left to right firing rate displayed on a pseudocolor scale vs DC step and E_GABA when the LIF model received 33 randomly occurring GABA_A events/s in control conditions (left), when GABA_A activity induced only transient changes in I_GABA-A (middle) or when GABA activity induced only transient changes in R_in (right). h, CV_ISI displayed on a pseudocolor scale vs firing rate and E_GABA. Same conditions as in g.