Skip to main content
. Author manuscript; available in PMC: 2011 Jul 15.
Published in final edited form as: Ann Thorac Surg. 2008 May;85(5):1678–1685. doi: 10.1016/j.athoracsur.2008.01.043

Fig 4.

Fig 4

Effect of tumor necrosis factor (TNF)-α and interleukin (IL)-1β on postischemic cardiac functional recovery in Toll-like receptor 4 (TLR4)-defective hearts. TLR4-defective (TLR4-def) hearts underwent 20 minutes of global ischemia followed by 60 minutes of reperfusion, and were treated with TNF-α and IL-1β (0.1 ng/mL each) during reperfusion. Postischemic (A) left ventricular developed pressure (LVDP) and (B) +dP/dt max were similar in TLR4-defective hearts treated with TNF-α and IL-1β (TLR4-def + Cytok, black circles) and wild-type (WT, white squares) hearts, and significantly lower than in untreated TLR4-defective hearts (white circles). Data are expressed as mean ± SEM; n = 6 in each group; *p < 0.05 vs WT; #p < 0.05 vs TLR4-def.