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Renal fibrosis and kidney weights 6 weeks after treatment of male ZL and ZDF rats with vehicle (con) or SO extract. The renal van Giesen-stained collagen deposit area and the total renal tissue area were determined by image analysis. (a)–(d) Representative samples of renal fibrosis (red) (magnification 200×); (e) the ratio of the area of collagen accumulation to the total renal tissue area; (f) kidney weight. All values are means ± SEM (n = 5, each group). *P < .05.
