Skip to main content
. Author manuscript; available in PMC: 2012 Jun 9.
Published in final edited form as: Neuron. 2011 Jun 9;70(5):924–938. doi: 10.1016/j.neuron.2011.03.027

Figure 8. Noggin and FXR2 are Colocalized in the DG but Not in the SVZ.

Figure 8

(A) Noggin (as shown by β-gal staining in NogginlacZ mice) and FXR2 were not expressed in the same cells of the SVZ.

(B) Noggin (red) is expressed in S100β+ ependymal cells (green) in the SVZ.

(C) Since ependymal cells also expressed Nestin (green), Noggin (red) partially overlaps with Nestin. However, Noggin is not expressed in GFAP (white) or Nestin double-positive stem cells in the SVZ. Blue, DAPI.

(D) Noggin (red) and FXR2 (green) were coexpressed in the same cells of the DG. Noggin (red) is expressed in GFAP+ (green) radial glia-like NPCs in the DG.

(E) Noggin (red) is expressed in GFAP+ and Nestin (green) double-positive radial glia-like NPCs in the DG.

(F, G) Models of FXR2 and Noggin function in adult SVZ- (F) and DG- (G) NPCs. In the SVZ (F), Noggin is expressed by ependymal cells, while FXR2 is expressed by stem cells; therefore, FXR2 does not regulate Noggin expression. However, in the DG (G), FXR2 and Noggin are coexpressed in the stem cells (and also granule neurons); therefore, the expression levels of Noggin are under FXR2 control. FXR2 thus specifically regulates the fate of DG-NPCs by repressing Noggin expression, thereby enhancing BMP signaling. All scale bars = 20 μm. (Also see Figure S6 and Figure S7.)