Figure 1.

The effects of Continuous treadmill training on axon regeneration in peripheral nerves. Cut common fibular nerves in thy-1-YFP-H mice were repaired with a short length of nerve harvested from a non-fluorescent littermate. Animals were trained continuously for one hour per day at a slow treadmill speed (10 m/min), five days per week for no more than two weeks. Using images of optical sections made through these grafts, the lengths of YFP+ regenerating axon profiles were measured at different survival times. Average median axon profile lengths, expressed as a percentage of untrained controls (±SEM, N=4 for each), are shown. The horizontal dashed line at 1.0 indicates the length of regenerating axons in untrained controls. Data are from Sabatier et al (2008).