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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Cell Calcium. 2011 Mar 5;50(2):129–138. doi: 10.1016/j.ceca.2011.01.010

Figure 3. Ca2+ release from acidic vacuoles in S. cerevisiae cells.

Figure 3

The vacuolar TRPC-family ion channel (Yvc1) becomes rapidly activated in response to hydrogen peroxide (H2O2) or tert-butylhydroperoxide (tBOOH). Hypertonic shock (e.g. high salt or sugar in the environment) triggers a slower activation of Yvc1, possibly through stretching of the vacuole membrane. Both stimuli result in transient elevation of [Ca2+]CYT that is reversed by the actions of vacuolar Ca2+ transporters (Pmc1, Vcx1). The activation of downstream signaling pathways has unknown functions.