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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Metabolism. 2011 Apr 12;60(9):1259–1270. doi: 10.1016/j.metabol.2011.01.008

Figure 7. Effect of Uric acid on Rat Pancreatic Islet Cells.

Figure 7

Pancreatic RIN-m5F cells were exposed for 48 hours to varying concentrations of uric acid in the presence or absence of the URAT-1 inhibitor probenecid (1 mM). Uric acid (UA, 6 mg/dl) significantly increased the mRNA expression of the inflammatory markers KC (Fig A), MCP-1 (Fig B) and IL-6 (Fig C). Uric acid ( 3 and 6 mg/dl) also stimulated oxidative stress, as assessed by oxidized DCF fluorescence (Fig D). that the effects of uric acid to induce cytokine expression and oxidative stress was blocked by probenecid (2 mM) (Figs A–D)