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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Cancer. 2011 Oct 1;117(19):4424–4438. doi: 10.1002/cncr.26073

Figure 7. DAC and SAHA inhibit growth of xenograft tumor and induce autophagy.

Figure 7

(A) Mice were injected i.p. with Hey (1×106) cells. Two days later, mice were injected i.p. with (1) saline (control) (2) DAC, (3) SAHA, and (4) a combination of DAC and SAHA as described in Materials and Methods. Five mice from each group were evaluated daily for survival. (B) Hey xenograft tumors were treated as indicated for 21 days before they were harvested and processed for TEM. The arrows indicate the autophagosomes. N, nucleus; M, mitochondria.